Ramipril 2.5 mg Tablet is an antihypertensive medication that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby relaxing blood vessels, lowering vascular resistance, and reducing blood pressure. Ramipril also decreases aldosterone secretion, leading to reduced sodium and water retention, which further aids in controlling blood pressure and reducing cardiac workload. The 2.5 mg strength is typically used as a starting dose in patients with mild to moderate hypertension, heart failure, or as an initial dose following myocardial infarction in high-risk patients. Ramipril not only controls blood pressure but also offers cardioprotective and renoprotective benefits, making it valuable in patients with diabetes, chronic kidney disease, or those at high risk of cardiovascular events.
Common side effects include dizziness, headache, fatigue, and dry cough (a class effect of ACE inhibitors). Some patients may experience low blood pressure (hypotension), nausea, or gastrointestinal discomfort. Rare but serious adverse effects include hyperkalemia, angioedema (swelling of the face, lips, or throat), and impaired kidney function. Patients should report any signs of swelling or difficulty breathing immediately.
Ramipril 2.5 mg Tablet is indicated for the treatment of essential hypertension, congestive heart failure, and as part of therapy to reduce the risk of myocardial infarction, stroke, and cardiovascular death in high-risk patients. It is also used for slowing the progression of diabetic and non-diabetic nephropathy.
Ramipril 2.5 mg should only be used under medical supervision. It is contraindicated in pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Caution is advised in patients with severe kidney impairment, bilateral renal artery stenosis, or a history of angioedema. Potassium supplements or potassium-sparing diuretics should be avoided unless specifically prescribed, as ACE inhibitors can increase serum potassium levels. Alcohol consumption should be limited as it can enhance the blood pressure-lowering effect. The medication should not be discontinued abruptly without consulting a physician. Regular monitoring of blood pressure, kidney function, and electrolytes is recommended during long-term use.
Store Ramipril 2.5 mg Tablet in a cool, dry place below 30°C. Protect it from moisture and direct sunlight. Keep out of reach of children and pets. Do not use the tablet beyond the expiry date mentioned on the strip or packaging.