Metofoli 400 Tablet contains Metronidazole 400 mg, an antiprotozoal and antibacterial agent used to treat a wide range of infections caused by anaerobic bacteria and certain parasites. It works by disrupting the DNA structure of microbial cells, inhibiting nucleic acid synthesis, which leads to the death of the pathogens. Metronidazole is particularly effective in treating infections of the gastrointestinal tract, genitourinary tract, skin, joints, and respiratory system. It is also widely used in the management of bacterial vaginosis, pelvic inflammatory disease, amoebiasis, giardiasis, and infections caused by Clostridium difficile. Metofoli 400 is an essential medicine in both outpatient and hospital settings due to its broad-spectrum efficacy against anaerobic organisms. Its oral formulation allows for easy and convenient administration, making it a go-to treatment for a variety of infectious conditions.
Common side effects of Metofoli 400 Tablet include nausea, metallic taste in the mouth, loss of appetite, abdominal discomfort, and headache. Less commonly, it may cause dizziness, dark-colored urine, dry mouth, or vomiting. Rare but serious side effects include seizures, peripheral neuropathy (tingling or numbness in hands or feet), and allergic reactions such as rash or swelling. Prolonged use should be avoided unless advised, as it may lead to fungal overgrowth or secondary infections.
Metofoli 400 Tablet is indicated for the treatment of anaerobic bacterial infections and protozoal infections. Specific indications include amoebiasis (intestinal and hepatic), giardiasis, trichomoniasis, bacterial vaginosis, pelvic infections, pseudomembranous colitis, dental infections, and surgical prophylaxis where anaerobes are likely. It is also used as part of combination therapy for Helicobacter pylori eradication in peptic ulcer disease.
Metofoli 400 Tablet should be taken exactly as prescribed by a healthcare professional. It should not be consumed with alcohol during the course of treatment and for at least 48 hours after the last dose, as it may cause a disulfiram-like reaction (nausea, vomiting, flushing, and headache). Use with caution in patients with liver disease, central nervous system disorders, or a history of blood dyscrasias. Pregnant and breastfeeding women should use this medication only under medical supervision. Do not discontinue the medicine early, even if symptoms improve, to avoid recurrence or resistance.
Store Metofoli 400 Tablet in a cool, dry place below 30°C. Protect from moisture, direct sunlight, and heat. Keep the medication in its original packaging and out of reach of children. Do not use the tablet beyond its expiry date.