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Donetyle 5 Tablet

Composition : Donepezil HCl (5mg) + Memantine HCl (5mg)

Dosage Form : Tablet

Packaging Type : Alu Alu

Packaging : 10*10

Price : ₹75/-

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Donetyle 5 Tablet is a combination therapy designed to manage symptoms of Alzheimer’s disease and moderate to severe dementia. Donepezil is an acetylcholinesterase inhibitor that increases the levels of acetylcholine in the brain, thereby enhancing cholinergic transmission, which is often deficient in Alzheimer’s patients. Memantine is an NMDA (N-methyl-D-aspartate) receptor antagonist that regulates glutamate activity, preventing excitotoxic neuronal damage while preserving normal synaptic transmission. Together, this dual-action formulation addresses both cholinergic deficit and glutamatergic overactivity, providing symptomatic improvement in memory, cognition, and daily functioning. The 5 mg + 5 mg strength is typically used as a starting or maintenance dose under physician supervision.

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About the Product

Donetyle 5 Tablet is a combination therapy designed to manage symptoms of Alzheimer’s disease and moderate to severe dementia. Donepezil is an acetylcholinesterase inhibitor that increases the levels of acetylcholine in the brain, thereby enhancing cholinergic transmission, which is often deficient in Alzheimer’s patients. Memantine is an NMDA (N-methyl-D-aspartate) receptor antagonist that regulates glutamate activity, preventing excitotoxic neuronal damage while preserving normal synaptic transmission. Together, this dual-action formulation addresses both cholinergic deficit and glutamatergic overactivity, providing symptomatic improvement in memory, cognition, and daily functioning. The 5 mg + 5 mg strength is typically used as a starting or maintenance dose under physician supervision.

Common side effects include nausea, vomiting, diarrhea, headache, dizziness, fatigue, and loss of appetite. Some patients may experience insomnia, muscle cramps, or abdominal discomfort. Rare but serious side effects include bradycardia, hallucinations, seizures, or hypersensitivity reactions. Memantine may cause mild hypertension or confusion initially, which usually subsides with continued use.

Donetyle 5 Tablet is indicated for the management of moderate to severe Alzheimer’s disease and other types of dementia where both cholinergic and glutamatergic pathways are involved. It helps improve cognitive functions, behavior, and the ability to perform daily activities.

Donetyle 5 Tablet should only be used under strict medical supervision. It is not a cure for Alzheimer’s disease but helps manage symptoms and slow cognitive decline. Dose titration should be done carefully to minimize side effects, and abrupt discontinuation is not recommended without consulting a physician. Caution is advised in patients with cardiac conduction disorders, seizure history, peptic ulcer, or severe renal impairment. It should be used with care during pregnancy and lactation only if benefits outweigh the risks. Alcohol and other CNS depressants should be avoided as they may exacerbate side effects such as dizziness and confusion. Caregiver supervision is essential to ensure adherence and monitor response.

Store Donetyle 5 Tablet in a cool, dry place below 30°C, away from moisture and direct sunlight. Keep the tablets in their original blister packaging and out of the reach of children. Do not use beyond the expiry date mentioned on the strip.

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